Identification of novel human cancer-specific antigens Literature review

Identification of novel human cancer-specific antigens - Literature review Example   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Likewise, opportunities to develop cancer treatment demonstrated promising results (Haffner et al., 2001; Jager, Jager, and Knuth, 2002; Fijak and Meinhardt, 2006; Park, Lin, Nishidate, Nakamura & Katagiri, 2006;   Tabi and Man, 2006;   Ã‚  Hayashi et al., 2007; Meklat et al., 2007; Dakshinamurthy, Ramesar, Goldberg and Blackburn, 2008; Hunder et al., 2008; Old, 2008; Caballero and Chen, 2009; Chen et al., 2009; Dubovsky et al., 2009; Fard and Modaressi, 2009; Vujanovic and Butterfield, 2009). Consequently, pioneering research in the search for effective cancer vaccines has produced cancer/testis antigens such as MAGE, GAGE, and NY-ESO-1 which are currently undergoing clinical trials (Mashino et al. 2001; Bowlus, 2007; Gierstoff and Ditzel, 2008). Each year more cancer/testis antigens are being identified, creating more opportunities for research and increasing the chances of developing cancer vaccines that can be used not only for treatments, but for prevention as well (Jager, Jager, and Knuth, 2002). Also, research on cancer/testis antigens has brought to light important discoveries on how mechanisms of cancer development work at a molecular level (Alters, 2000; Old, 2001; Gjerstoff, Kock, Nielsen and Ditzel, 2007; Delbridge, 2010; Inagaki, Schoenmakers and Baarends, 2010; Suzuki et al., 2010). Moreover, studies on the link between chromosomes and immune responses reveal that some cancers are more prevalent in males than in females. In addition, results also show that females may have higher cancer survival rates but are more susceptible to autoimmune diseases (Libert, Dejager and Pinheiro, 2010). Further research on the role of cancer/testis antigens should be conducted, particularly in determining the mechanisms that initiate cancer in the first place. Also, further studies should be performed to developed better cancer diagnostic methods and combination immunotherapy

Lower division capstone ip4 Essay Example | Topics and Well Written Essays - 500 words

Lower division capstone ip4 - Essay Example Recently, Foxconn Technology Group workers went on strike demanding better working conditions. As a supplier to many blue-chip companies, Foxconn failed in the area of employee empowerment. Instead of a strike which is detrimental to the progress of a company, empowered employees seek negotiations. As the senior manager in such a situation, I would have sought dialogue and not ignored the workers’ grievances. The other theory in this case would be the alternative dispute resolution theory. This would include the resolution of all issues that come about without a need to seek legal advice or going on strike. The theory of penetration pricing advocates for offering lower prices for given products during their introduction into the market to drive away competition. The benefits of applying this method lay in the aspect of attracting customers away from the competition. If applied correctly, penetration pricing can be a very successful marketing method which could increase a company’s sales volume and market share. The high sales volume often realized by this method could translate to lower production costs or a higher inventory turnover or both. The application of this theory therefore comes about as a method for entering the market especially when it is almost crowded by similar products by competitors. In the recent past, smartphone company Apple has introduced mobile phones with lower prices to enter the mainstream market. Apple is known for making products that are aimed at the luxurious consumer but had to enter the lower-end market to keep its market share. If I were the senior manager in this case, I would ensure that the lower-end market remains catered for by the penetration pricing model by increasing the quality of the gadgets offered compared to the competition. Another theory in such a case would be the theory of market segmentation. This theory also advocates for the division of markets with the

Listening and Paraphrasing Essay Example for Free

Listening and Paraphrasing Essay The first person I interviewed was my sister’s friend who is nineteen years old and is in college. She works part-time a crew in a coffee shop just outside our village. I asked her about her job and how she was able to manage her time juggling work and studies. According to her, what she is doing is tiresome but she was able to do both activities since it is not simultaneous and that, she really has to be able to do so. She mentioned how she prioritizes work over her studies. She attends to her class regularly but admits that, most of the time, she isn’t attentive. She said that she had to miss some of her morning classes because she’s too tired to get up in the morning. She gets to miss several classes but never miss even a minute of work. She told me that she doesn’t resent having to work while studying unlike other students because she believes that she is learning more and is getting personally better when she is forced to work and study at the same time. She takes everything as a training for what else worse that could happen. She said she feels like there’s nothing that she won’t be able to get through because she has gotten stronger after all the early struggles in her life. She also said that her job as a crew is not all about the money she is earning. She said that she is also enjoying the work because she wants to put up business someday and she is planning to pursue food business. She has been learning a lot by working and feels more unfortunate than other students because she was able to directly apply what she learns from school. In this interview, I would have to repeat some of her answers to make it appear that I am deeply interested in what she is saying. I have learned that paraphrasing also eliminates bars between two communicating parties because it makes one believe one is interested with the other’s tales (USDVA, 2004). When I repeat what she tells me, I say it in a different manner like this one time when she said, â€Å"I really don’t mind if I don’t get too good grades. Passing is enough for me. I just know that I am more knowledgeable than them and I understand exactly what the principles are saying. They only know it by words! † I would say, â€Å"You are no longer after the high grades because you know you understand the subject very well and school grades are just evaluation of school performance. † And I would follow it immediately with a question to keep our conversation going. The next person I interviewed is my grandfather who is already seventy-eight. We’ve talked about his life as part of the navy, how he met my grandmother and who is his favorite among his children. The talked about who is his favorite child is the most interesting part of our conversation. He said, â€Å"Your father wouldn’t lift a hand to reach something and would wait for his siblings or his mother or me to pass by so we could reach it for him. † I said, â€Å"My dad wouldn’t bother himself trying to reach something and would have to rely on someone else so he could get that something. † Having to repeat their words would mean understanding the matter more clearly (RMIT, 2005). It is also a tool for clarifying ideas. In communication, it is very effective because when one feels that the other understands him, he feels more comfortable to talk about anything without any hesitations (Rowley, 2002). I was able to demonstrate it when I was able to extract information from my sister’s friend that is in a more personal level and when I was able to let my grandfather to bring back the memories he had with my father. References: RMIT University. 2005. Paraphrasing. Study and Learning Center, RMIT. Retrieved February 10, 2009 from http://www. dlsweb. rmit. edu. au/lsu/content/4_WritingSkills/writing_tuts /paraphrase_LL/index. html. Rowley, Richard. 2002. Active Listening. Retrieved February 10, 2009 from http://www. aligningaction. com/activeli. htm. U. S. Department of Veterans Affairs. 2004. Listening to Paraphrase. Retrieved February 10, 2009 from http://www1. va. gov/adr/page. cfm? pg=46.

Development of Artificial Sweat Experiment

Development of Artificial Sweat Experiment 3.0 Literature Review : 3.1 Biosensor The terminology for biosensor is usually used for equipment or devices used to monitor the metabolic system or element of biomocules. In addition, the particular term used, is referring to a sensor that uses a biological element, such as enzymes, antibodies, DNA, microorganisms or cell. Besides that, based on the IUPAC,it state that biosensor is an integrated equipment that have the capability to give a good analytical data and information in terms of qualitative and quantitative by using the element of biological recognition that interact with the transducer. Figure 1.1 and 1.2 show the schematic diagram. Gambar Rajah dalam buku 3.1.1 Structural Component of Biodetection The partition in a biosensor that can operate with optimum condition consists of 3 components which are, (a) Bio-recognition elements, where the biomolecules are being placed and integrated which normally known as the immobilization on the surface of sensor, (b) Transducer or Detector devices, where the electrochemical and optical transduction occurs, (c) Processing Signal. Gambar rajah dalam buku 3.1.2 Immobilization Bioreceptor In the development of biosensors, the bioreceptors or biomolecules are important in selectively and add with the sensitivity to certain analytes, to ensure that they need to be situated and connected with a transducer in order to achieve the effectiveness of the biosensor in detecting certain analyte. The immobilization bioreceptor’s techniques involves, Adsorption, Microencapsulation, Entrapment, Covalent Attachment and also Cross-Linking. (gambar rajah dalam buku) 3.1.3 Performance of Biosensor In the development of biosensors, things that should be emphasized is the operated performance of the biosensor in detecting analytes. The biosensor performance covers the aspects of the selectivity, sensitivity, accuracy, solution conditions, the â€Å"responds time† ( tr), the â€Å"delay time† (td) and also the â€Å"lifetimes†. 3.1.4 Application Related to Smart Wearable of Biosensor For Sweat Sensor There are various types of application in sensors that already applicable in the market, such as Smart Bra, Thick-film textile-based amperometic sensors and biosensors, Global Positioning System, Wireless Hands-free Communication, Smart Shirt and the most important sensor, is Smart Sensor that will be discussed in this research. (gambar smart patch) 3.2 Sweat Generally, we know that sweat is excreted by sweat glands while the other term in this review, define the term for human sweat as nonexercise-induced eccrine (thermoregulatory) sweat which is secreted by healthy person and but not focusing on the Apocrine. A person, body region, diet, season, degree of acclimation, activity level ,race ,gender ,and also the sampling techniques can give high possibility affect to the variety in the composition of sweat between an individual. (Buckley and Lewis, 1960; Shirreffs and Maughan, 1997; Patterson et al., 2000, 2002; Hayden et al., 2004; Morgan et al., 2004; Shirreffs and Maughan, 1997; Jacobi et al., 2005; Robinson and Robinson, 1954). 3.2.1 Composition of Sweat : Human sweat is composed of highly variable amounts of primary electrolytes, ionic constituents, organic acids and carbohydrates, amino acids, nitrogenous substances, and vitamins and miscellaneous constituents (Fig. 1). Sweat is 99.0–99.5% water and 0.5–1.0% solids (half inorganic and half organic), with specific gravity of 1.001– 1.008 (Robinson and Robinson, 1954; Rothman, 1954; Spector, 1956; Geigy, 1970, 1981; Altman and Dittmer, 1974; Agache and Candas, 2004). Nevertheless, this research report only focusing in the electrolyte, organic acids and carbohydrates and also pH. 3.2.1.1 Electrolytes In general, concentrations of electrolytes in sweat were highly changeable and can assume to be countless. The major constituents of electrolyte were Na and Cl, and the minority amounts were consists of Ca, K, and PO4 (Robinson and Robinson, 1954; Rothman, 1954).In addition, there was reported in a journal that stated, the concentrations of primary electrolytes in the 45 formulations of artificial SSFL which were generally within ranges for human sweat. Unfortunately, median value were not be equivalentl to human sweat.There was lot of formulations lacked of many of the electrolytes present in human sweat (Fig. 1a). In such a case, some are as minimal as a solution of Na and Cl ions (Chiba et al., 1997; Mawn et al., 2005) while there was also occurred among the 45 formulations of artificial SSFL, 7 lacked Na ,8 lacked Cl, 41 lacked Ca, 38 lacked K, 44 lacked Mg, 34 lacked PO4, and all lacked HCO3 (Table 1). 3.2.1.2 Organic acids and carbohydrates The summary in Fig. 1c was shown the measurement of the concentrations of organic acids and carbohydrates which was reported in human sweat. (Mickelsen and Keys, 1943; Robinson and Robinson, 1954; Rothman, 1954; Kuno, 1956; Spector, 1956; Elze and Oelsner, 1957b; Reed, 1969; Geigy, 1970, 1981; Altman and Dittmer, 1974; Kaiser et al., 1974; Stu ¨ttgen and Schaefer, 1974; Goldsmith, 1999; Guyton and Hall, 2000; Agache and Candas, 2004).However, Lactic acid was plentiful of these constituents and its average constitutes was 0.28% of sweat (Spector, 1956; Altman and Dittmer, 1974). Besides that, by reffering to the published Journal of SSFL, acidity of SSFL was due to the high concentrations of both lactic acid and pyruvic acid (Agache and Candas, 2004). The concentrations of organic acids and carbohydrates in 45 artificial SSFL formulations are also summarized in Fig. 1c. The concentration of lactic acid and glucose in artificial SSFL formulations were generally within ranges outlined for human SSFL. 3.2.1.3 pH The measurement of pH values for whole body are summarized in Table 2 (median = 5.3). Values of whole body sweat in Table 2, are from a very acidic pH 2.1 (Haudrechy et al., 1997) to an alkaline pH 8.2 (Altman and Dittmer, 1974). There was might be a variety of sweat pH during a period of sweating, either it become less acidic or more acidic (Robinson and Robinson, 1954) and by body region (Collins, 1957). In order to analyze the effects of alkaline sweat, an investigation had been done by using the pH greater than 7. (Jordinson, 1941; Collins, 1957; Brown et al., 1982; Emmett et al., 1988, 1994; Wainman et al., 1994; Schimper and Bechtold, 2005.Due to the various in sweat pH, many investigators have studied dissolution of a test article over a range of pH values (Gallay and Tapp, 1941; Collins, 1957; Brown et al., 1982; Hemingway and Molokhia, 1987). 3.2.2 Physiology of sweat There are two main types of sweat gland, apocrine and eccrine. Apocrine glands are the largest and they produce a viscous sweat containing lipids, cholesterol and steroids [12,13]. Eccrine glands operate almost the whole body and its amount between 2 and 4 million glands in adult skin. Thermoregulation is regulated by the eccrine sweat glands that helps in maintaining a constant body temperature, and hypothalamus become the centre in controlling the physiological sweat with normal rate of secretion ranging from 0.5 to 1mL/min. The characteristics of sweat is a clear hypotonic, and odourless fluid which consists of sodium, chloride, urea, lactate, organic and non-organic compounds [16]. The acidic nature of the excreted sweat is due to transportation and reabsorbing processes, which are relied on the physiological conditions that occur in the duct [17]. For instance, Patterson et al. has proven that the increased blood and sweat pH through the ingestion of sodium bicarbonate is caused by the induction of metabolic alkalosis. However, it is thought and assumed, this is because of the reduced sweat acidification in the reabsorbtive duct of the sweat glands. Furthermore, the relationship of sweat pH to sweat rate [9,15] and even for relationship of pH and sodium (Na+) levels in isolated sweat glands shown that they are directly proportional to each other. It is known that induce active sweating in human beings will give affect to the heat, mental stimuli, muscular exercise and carbon dioxide [20,21] as the sweating is continued to occur as long as the stimulation lasts and subsides quickly after it ends.. 3.2.3 Sweat collection and analysis The characteristics of sweat sampling and the special samples it requires deserve discussion separated from analysis that can be either different or similar to that in other biofluids. Nowadays, the purposes of sweat analysis are used even in optimizing the performance of athletes by studying the effects of dehydration but in the diagnosis of disease, detection of drug abuse, a method for testing deodorants .In addition, there are a lot of availability of different methods for the purposes of sweat collection and testing. However, the original method to test the components of sweat after exercise was revealed by using the whole bodywash down technique. Hence, all fluids lost during the aerobics are being stored for analysis [18].The following method was, sweat collection devices consisted of an occlusive bandage formed by one-to-three layers of filter paper, gauze or towel [5]. However, this kind of patch was time-consuming to apply, uncomfortably large, prone to detachment and yielded a small volume of sweat for analysis. In addition, it was found to alter the steady-state pH of the skin, the types of bacteria that colonize the skin and the transport characteristi cs of the skin, producing skin irritation [6]. To overcome these difficulties, non-occlusive sweat collection devices were developed, consisting of an adhesive layer on a thin transparent film of surgical dressing to which a absorbent pad and the overall being attached to the arm radial region. The transparent film just allow oxygen, water and carbon dioxide to pass through the patch, leaving healthy the underneath skin and prevents from the penetration of the non-volatile substances from the environment [5] .During wearing of the patch, sweat saturates the pad and slowly concentrates it, sweat components are retained, while water evaporates from the patch, thus misleading results of chloride concentration. Hence, its design does not allow to quantatize the concentrations of analytes in sweat, since the whole volume of secreted sweat is unknown. However, there is a commercial devices for sweat sampling are usually linked to subsequent determination of a given analyte by a dedicated instrument into which the sampler is inserted, as is the case with sweat collection for diagnosis of CF [10]. A recent, no validated sampler for a given application that circumvents sweat-volume related problems and fulfills the present trend to microdevices is a microstrip impregnated with a dye pH indicator [11]. A key aspect of sweat sampling is its noninvasive character, crucial in dealing with people such as hemophiliacs, blood sampling of whom is an either difficult or dangerous task. Sweat sampling can avoids risk of infections to patients who need daily analysis, rather than compared with urine, sweat sample preparation is less complex. Therefore, the use of sweat for commonly frequent analysis practices such as drug control in athletesis preferable. In short, sweat as clinical sample is almost free from impurities or interferents and sample preparation is simple and fast step is quite enough. The main limitations of sweat as clinical sample are the difficulty to produce enough sweat for analysis, sample evaporation, lack of appropriate sampling devices, need for a trained staff, and errors in the results owing to the presence of pilocarpine. In dealing with quantitative measurements, the main drawback is normalization of the sampled volume. Later on, the method has been discovered within the framework to produce results with a high coefficient of variation, which has lead to the development of sweat collection patches or capsules [22]. For instance, a disposable sweat collector developed by Brisson et al. that consisted of capsule created inside a flexible adhesive membrane pasted onto the skin [23]. After that, these collected samples are then stored at low temperatures for later analysis in a laboratory. Now, the pH of sweat can only be determined when the subject has already finished exercise and does not give any changes in the results which might occur between the beginning and end of an exercise session. Therefore, it can be validate that a real-time, wearable method of gathering and analysing sweat is preferable and in demand. Generally, this paper explains about the Development of Smart Patch with On-line Sweat Analysis .Besides that, artificial sweat has been chosen as it is an easily accessible fluid sample. The expected applications of this system for the personal health and sports performance and training. 3.2.3.1 Sweat analysis Sweating is naturally increased by nervousness, exercise, stress and nausea, and decreased by cold. Sweat excretion is also affected by other factors, such as ambient temperature, relative humidity, body location, hormonal imbalances, overactive thyroid gland and the sympathetic nervous system, and certain foods and medications A potential, general personal use of sweat is the recently developed smartphone application for in situ colorimetric detection, in prepared microchips, of pH changes in sweat correlated with chloride concentration and sweat rate which, during physical exercise, can indicate to users the proper time for hydratation [11]. 3.2.3 Artificial Sweat : 3.2.3.1 Historical of Artificial Sweat : The term artificial sweat is used throughout this review and encompasses historically used terms such as ‘‘artificial sweat,’’ ‘‘acidic artificial sweat,’’ ‘‘artificial perspiration,’’ ‘‘synthetic perspiration,’’ ‘‘synthetic sweat,’’ ‘‘sweat simulant,’’ and ‘‘simulated sweat.’’. 3.2.3.2 Benefits of a comprehensive artificial sweat Historical formulations of artificial sweat do not appear to have been characterized and often lacked many constituents present in human sweat. However, only four artificial formulations included more than one amino acid. No vitamins were included in any previous formulation of artificial sweat. Among all historical formulations, one of the most chemically comprehensive recipes was developed by Boman et al. (1983) but contains only select electrolytes, ionic constituents, organic acids, and amino acids. The novel formulation presented herein contains the known human sweat constituents at physiologically relevant levels which provides for a more accurate representation of human than previous artificial sweat models. Our novel artificial sweat formulation with composition that matches human is a chemically complex solvent. Preparation of this artificial sweat requires time and costs not associated with simpler formulations containing only the main constituents of sweat. However, caution must be used when excluding constituents. 3.2.3.3 Comparison to human sweat During formulation, we first balanced all ionic constituents and electrolytes except sodium and chloride. Additionally, concentrations of many human sweat constituents vary widely due to factors such as age, diet, season, degree of acclimation, and gender, making it difficult to design an artificial sweat solution that is universally valid. The artificial sweat formulation described in this paper is chemically more comprehensive than any of the 45 previously identified artificial sweat formulations and contains constituents that are nearly all present in concentrations that match median values in human sweat. However, in our review (Stefaniak and Harvey, 2006), we provided estimates of human sweat constituent concentration ranges, pH, and temperature variability that could be used to guide investigations of the relative importance of sweat factors on interactions with materials. In summary, our artificial sweat, represents a novel comprehensive artificial sweat at median constituent concentrations which equivalent to humans. (Stefaniak et al., in press),

Gawains Encounter with the Green Knight in the Green Chapel Essay

Gawain's Encounter with the Green Knight in the Green Chapel Even though little is known about the author of Sir Gawain and the Green Knight, it is considered to be one of the greatest romances of all time. The poem tells the story of one of Arthur's noblest and most courageous knights, Sir Gawain, who is in search of the Green Chapel: "Sir Gawain ingeniously combines two plots, common in folklore and romance, although not found together elsewhere: the beheading contest, in which two parties agree to an exchange of blows with a sword or an ax, and the temptation, an attempted seduction of the hero by a lady" (Norton 200). The poem Sir Gawain and the Green Knight deals with important themes and ideas such as nobleness, chivalry, knighthood, Christian ideals, truth, temptation, and hunting among others. The poem is also a "study [of] how successfully Gawain, as a man wholly dedicated to Christian ideals, maintains those ideals when he is subjected to unusual pressures" (Norton 200). The poet effectively uses literary devices such as alliteration , rhyme, irony, metaphor, symbolism, and imagery to reinforce his ideas and themes. This passage of Sir Gawain and the Green Knight deals with Gawain's encounter with the Green Knight in the Green Chapel. The guide describes the Green Knight as a big, cruel, scary monster. He tells Gawain that because of his cruelty, no one wants to get in the vicinity of the Green Knight. He warns Gawain to not risk his life by going to the Green Chapel, and promises him that he will conceal everything. However, Gawain must face the Green Knight and face the hit, because he is noble, worthy, and courageous. He is not a coward. He says to the guide, "But though you never told the tale, if I turned back... ...reen belt has magical protection and can save his life. Gawain's failure shows that he too is human and has faults. Works Cited Abrams, M. H. et al. The Norton Anthology of English Literature. Vol. 1. Sixth Edition. New York: W.W. Norton, & Co. 1993. 200-254. Bobr, Janet. Origin. 1998. December 2, 1998.Online. Internet. Available http: csis.pace.edu/grendel/prjs2f/gawain2.htm Finker, Leonid. Sir Gawain the Noble Knight. 1996. December 2, 1998. Online. Internet. Available http: csis.pace.edu/grendel/proj2a/sirgaw.html Hannabery, Brian. Sir Gawain and the Green Knight--The introduction. 1998. December 2, 1998. Online. Internet. Available http: csis.pace.edu/grendel/prjs3b/intro.htm Sera, Joe. Sir Gawain and the Green Knight--Close Reading of Lines 130-202. 1997. December 2, 1998. Online. Internet. Available http:csis.pace.edu/grendel/projs3f/proj2.html

My Memories of the State Park Essays -- Personal Experience

When I think about my favorite childhood places to visit, one spot stands out above the rest. My parents took my family to the State Park every year on Columbus Day weekend. Cramped in a station wagon between my three other brothers in the back seat, I remember the car ride to seemingly take triple the amount of time it really took. The time that it took to get to the state park was always increased when my parents would stop for lunch at the half way point, something they did each and every time. I knew we were close when I saw a sign for the Mall. It was a very weathered sign on the side of an even more deteriorating barn that could not have been larger than a classroom. I always laughed to myself about this sign because even though the sign advertised the mall was four miles ahead, the lettering of â€Å"4 miles ahead† was in a text size that you could barely make out as a passenger in a car traveling fifty miles per hour. If you were not paying attention, you would mistake this element torn building as the actual mall and feel a slight pity for the poor town. Though, seeing this sign and feeling the pity was a small price to pay for nearly being at your favorite place on Earth and out of your cramped conveyance. Shortly after the sign, there are road signs for the State Park which lead you to a steep, winding mountain road. Going up this incline in an overstuffed, late model station wagon seemed like it took more time than the two hour car ride it took to get to it. Then, finally, a carved boulder on the right side of the road appeared and proclaimed â€Å"STATE PARK.† This rock always had special meaning to me. It was a massive stone that never shifted from where it settled probably several decades ago. Th... ...ss visitors great experiences and upon arrival to it, it will be your turn to have them. The State Park holds many other places that offer different sorts of ventures, but when you truly respect the land, the tiniest encounters often yield the largest rewards. When you forego visiting the popular tourist destinations and decide to make your own exploits, the possibility of experiencing true freedom is increased. Going to a crowded beachfront by the lake, waiting in lines for bathrooms or to buy worms for fishing has less potential for adventure than simply walking into the woods without so much as a destination. There, in the woods, you will forget for hours that you live in society. Shortly after that absence of thought, you will find yourself doing unexpected and fulfilling activities that will shape your mind and outlook on life for as long as you live.

Adults and Children Essay

A gated community is a type of residential community that upholds privacy and exclusivity. Residential houses within gated communities are bounded within limited proximities that are bordered by walls, gates, fences, and such. Access or entrance to gated communities is highly restricted not only for pedestrians, but also to various types of transportation as well. Within gated communities, residents are provided with services or amenities that are exclusive only to them. Sometimes, gated communities adapt the concept of larger communities by providing services and amenities that will allow residents to enjoy a comfortable home and lifestyle within the bounds of the area. Large-scale and highly private or exclusive gated communities even provide small to medium sized shopping centers, recreational facilities, food and dining centers, and such that enables residents within it to enjoy daily living tasks and activities comfortable within its proximities. (Blandy & Lister, 287) The purpose of establishing gated communities is to provide the community with safe and secure housing opportunities for individuals allowing them to experience a peaceful and relaxed home environment. Security systems established within gated communities for limit access from non-residents ensure individuals that the area is sheltered and guarded from criminal activities. (McGoey) Another objective for the establishment of the concept of gated communities is to allow residents to control or manage the community or environment they live in by granting them the power or authority to supervise roles or activities within it. Gated communities are guarded by appointed security officers, but it is usually managed by a Homeowner’s Association – a group or organization which handles everything that has something to do with living within the gated community. The owners of the properties within the gated community gather and elect leaders who will be in charge of overseeing all needs, problems, concerns, and other issues that might require urgent attention and resolutions. In addition, gated communities also serve as housing facilities that promises to provide residents with the best quality of life by offering unlimited access to fun, entertainment, and privacy. For instance, some large-scale gated communities have golfing areas that are accessible only to residents. Residents are allowed to play within the golfing areas without any limitations. (â€Å"Explore Gated Communities! †) Due to the benefits and advantages of living in gated communities, some discussed previously, it has become a major trend in modern housing. (â€Å"Explore Gated Communities! †) However, although the positive attributes or aspects of gated communities have been discussed, there seems to be some issues raised on its influence or effect to the behavior and lifestyle of adults and children who live within and outside the community. Adults and children who live in and outside gated communities acquire both positive and negative qualities and perspectives from the context or dimensions of walled housing arrangements. The effects of living within gated communities vary from emotional and psychological, to moral and social influences. The remainder of this paper will discuss how the behavior and lifestyle of adults are influenced by the structure of gated communities. In terms of the relationship between adults and children, living within gated communities allows parents and older members of families to feel at ease with the whereabouts of their children within the community. The focus of gated communities on providing safe and secure home environments ensure parents that their children are safe without their close supervision as long as they stay within the confines of the gated community. (Le Goix, 2003) This helps them to focus on other urgent things or concerns as they feel no worries or stress regarding the safety of their children. On the other hand, parents who live outside gated communities feel the worry and stress due to the relocation or concentration of criminal activities outside the walls of gated communities. Since the difference between gated communities and the public is most observable in terms of safety and security measures, the distinction between these two kinds of communities gives way to the unequal division or distribution of criminal activities within the entire community. Criminal activities will converge on areas neighboring non-gated communities. (â€Å"Diagonal Mar – A Gated Community,†) This concern allows parents to feel worried or stressed about the safety of their children leaving them deeply involved with ensuring that they keep them protected at all times.